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In epidemiology, case fatality rate (CFR) – or sometimes more accurately case-fatality risk – is the proportion of people diagnosed with a certain disease, who end up dying of it. Unlike a disease's mortality rate, the CFR does not take into account the time period between disease onset and death. A CFR is generally expressed as a percentage. It represents a measure of disease lethality and may change with different treatments. CFRs are most often used for with discrete, limited-time courses, such as acute infections.